Closing date: 07/03/2025
MB-PhD Project: Resistin: Leukaemia’s Secret Weapon Against the Immune System
Lead Supervisors: Dr Kiran Batta
Co-Supervisors: Dr Mark Williams, Dr Jamie Honeychurch
Applications Deadline: Friday 7th March 2025
Project Keywords: Blood Cancers, Immune Suppression, Novel Therapies
Research Opportunity: Intercalated PhD, leading to the award of PhD and MBChB
Project Outline
Cancer cells employ a variety of mechanisms to evade detection by the body’s immune system, enabling their own growth and survival. Understanding these mechanisms could help restore the functional immune system and eliminate cancer cells. In our group, we have discovered that in myeloid blood cell cancers, the cancer cells produce excessive amount of a protein called Resistin. Preliminary data suggests that elevated Resistin levels in the plasma of myeloid cancer patients weaken their immune system and are associated with poor overall survival.
As a prospective student, your initial focus will be to investigate clinical parameters, such as the mutational signatures, immune cell landscape, and related comorbidities, that correlate with Resistin levels across myelodysplastic syndromes, myeloproliferative neoplasms and their overlapping diseases. This will help us stratify patients who may benefit from immunotherapy-related approaches and also serve as a biomarker for therapy response or occurrence of comorbidities e.g. cardiovascular events. Additionally, you will explore the molecular mechanisms by which Resistin contributes to immune suppression using state of the art techniques. This knowledge will help us develop novel strategies for targeting immune suppression and test them in patient samples.
As a member of our research team, you’ll collaborate with a multidisciplinary group of consultant haematologists and academic researchers at The Christie Hospital and Manchester Cancer Research Centre. You’ll also join a diverse international community of researchers focused on translational science. This studentship will provide opportunities to develop expertise in advanced cellular and molecular biology techniques e.g. transcriptomics, CyTOF, differentiation assays, cytokine profiling and biomarker identification. Furthermore, there is potential for collaborative work with our partners in the UK and Europe. You’ll receive invaluable mentorship from leading clinician-scientists and haematologists and have the opportunity to present your research at national and international conferences.
About Dr Kiran Batta (project Lead Supervisor)
Kiran Batta is a lecturer in cancer Biology in the Division of Cancer Sciences, The University of Manchester. In 2017, Kiran was awarded Oglesby Leukaemia Research Fellowship to start his independent group. Kiran’s research focuses on understanding epigenetic dysregulation leading to the onset and progression of leukaemia. In close collaboration with clinician scientists at The Christie hospital, Kiran’s lab is working towards identifying potential molecular targets for therapeutic benefit in leukaemia patients.
About the lab group
Find out more about Dr Kiran Batta’s lab group involved in this project and how we support your wellbeing, learning and career development.
As a supervisor, my role is to foster curiosity, cultivate critical thinking skills, and drive high-quality science that can impact lives. I aim to create an environment where my mentees can freely communicate their ideas, critically analyse their own and others’ research, support one another in their projects, and enjoy the process of researching and learning.
Our lab is a collaborative and welcoming environment where international researchers from undergraduate to senior postdoctoral levels work together. We are a friendly group who enjoy both scientific pursuits and socializing outside the lab.
The supervisory team meets weekly with you, but our doors are always open for you to drop in and discuss any questions. You are expected to present your work at our weekly lab meetings once every two months and are also encouraged to participate in student seminars organized at the Division or School level. We expect you to be passionate about your own projects, and the rest will follow.
A key goal of your PhD is to cultivate independent thought, project management, and innovation. I encourage students to start thinking independently from the outset. The scientific expertise gained in our lab will prepare you for a successful career as a clinician-scientist. Guidance from experienced clinician-scientists Drs. Wiseman and Williams will support your clinical career path. We encourage students to present at national and international conferences to build networks and advance their careers.
My mentorship extends beyond research guidance to include career development skills and support towards independence. I tailor my mentorship approach to each student’s individual needs and abilities.
I firmly believe that effective time management and a healthy work-life balance are essential for achieving research success. A healthy mindset is crucial for productivity and critical thinking, so I encourage my lab members to pursue hobbies outside of work.
Key information
Find answers to some common questions about our MB-PhD Studentships.
To apply to intercalate onto the PhD in Cancer Sciences component of the MB-PhD, you must meet the below criteria and satisfy the general requirements for permission to intercalate set by your institution, including passing all components of the MBChB at first attempt in the year prior to intercalation.
A University of Manchester MBChB student
- holding a BSc (hons) 2.1 or above in a relevant subject and in year 2 or year 3 of the MBChB or year 1 or year 2 of GEM; or
- currently studying in year 3 of the MBChB or year 2 of GEM
A University of St Andrews Medicine BSc (Hons) student on the Manchester course pathway:
- holding or predicted a BSc (hons) 2.1 or above and be intending to intercalate straight onto the MB-PhD ahead of your arrival in Manchester or by no later than between year 3 and year 4 of the Manchester MBChB programme
A University of Leeds MBChB student:
- currently studying in year 3 of the MB ChB
International applicants (including EU nationals) must ensure they meet the relevant academic eligibility criteria (including English Language).
The PhD component of the MB-PhD studentship is usually funded for three years, or four years in exceptional circumstances with prior agreement of MB-PhD Committee and supervisory team.
The studentship covers:
- An annual stipend of £21,000 per year to help with living costs
- Full funding for your PhD tuition fees (at the UK rate, with fee bursaries available for high-performing EU/International candidates)
- PhD project consumables and running costs, including costs for researcher development such as conferences and travel
- MBChB tuition fees (at the UK rate) for a maximum of four years
Here are our quick steps to apply for our MB-PhD:
1. Eligibility
First, you need to check you are eligible to apply for an MB-PhD. Please see the eligibility tab (above) to read all criteria.
2. Contact supervisors
You can explore the range of MB-PhD opportunities that are open to application on our Research Opportunities webpage.
We encourage you to contact the supervisor of any MB-PhD projects that you are interested in before starting your application. Having these conversations will help you to get a feel for the different research themes and projects on offer.
3. Register
Register to apply for our MB-PhD opportunities using the Postgraduate Application Form. You must create an account to register.
4. Create a new application
When you create a new application make sure you select the following:
- Academic Career – Postgraduate Research
- Mode of Attendance – Full-time
- Program Description – search for MB-PhD and then select the MB-PhD Programme
- Candidates apply for the MB-PhD programme – under ‘Research Title’ list MB-PhD Programme. You can provide supervisor preferences/research interests in your accompanying supporting statement and these will be considered at and after interview
- If you are shortlisted, you’ll be interviewed by the MB-PhD Programme Directors and Education Committee before being accepted onto the programme “in principle”. You will be matched with a supervisor based on your interview performance and project/research preferences
- If successful at interview, you will be asked to meet with a nominated MB-PhD supervisor in the subsequent week for them to review and approve your PhD offer
- For funding sources, please include the following information:
– Select ‘Yes’ from the drop-down
– Type of Funding: University of Manchester Scholarship
– Awarding Body: Cancer Research UK MB-PhD
– Status of Funding – Awarded
– Funding Covers – Fully Funded
– Leave the remaining boxes blank
5. Supporting documents
Your application form must be accompanied by several supporting documents:
CV
This should include:
- qualifications (GCSE, A-level or equivalent, and any higher education qualifications, including grades, and your current programme)
- academic prizes, research projects, and academics interests
- extracurricular interests, and activities and positions of responsibility relevant to your application
The information you provide in your CV will be considered in relation to widening participation, and/or university access policies, to ensure that all applicants are treated fairly.
Supporting statements
This should be 1,000 words maximum and include your reason for applying to the MB-PhD programme and your interest and suitability for the project. You can include project/research interest/s here and these will be considered at and post-interview.
References
You need to list two referees, one of which must be an academic referee from The University of Manchester, The University of Leeds or The University of St Andrews-Manchester pathway MBChB programme.
This could be a:
- Clinical debrief tutor
- PEP tutor
- Literature research project supervisor
- PPD tutor
References cannot be submitted by a supervisor named on the project you are applying for.
Supporting documents can be uploaded and submitted with the online application form.
If you have any issues, your supporting documents can be sent directly to the Doctoral Academy Admissions Team at admissions.doctoralacademy@manchester.ac.uk, CC’ing in mcrctraining@manchester.ac.uk.
6. Acknowledgement and review process
Once you have submitted your application form, we will email you with an acknowledgement.
We will review your application after the application deadline and once we’ve received all your supporting documents. If successful at interview, we will also share your application with a nominated supervisor(s) to review.
7. Interviews
7. Interviews
We will email you if you are invited to interview.
Interviews will take place at the Oglesby Cancer Research Building in Withington in Spring 2025.
8. Applying to intercalate
UoM MBChB students must complete an intercalation Expression of Interest form by Friday 24th January 2025 (we may be able to consider late applications to intercalate in exceptional circumstances). This form is available on 1MedForms via the following link: https://www.onemedforms.manchester.ac.uk/
UoL MBChB must apply to intercalate via UoL processes by Friday 24th January 2025.
University of St Andrews Manchester pathway students can contact mcrctraining@manchester.ac.uk for guidance.
Key dates
- Intercalation deadline: Friday 24th January 2025
- Application deadline: Friday 7th March 2025
- Interviews: w/c 28th April 2025
- Start date: September 2025
Useful Links
MB-PhD Studentships
Find out more about our MB-PhD Studentships which allow you to study a fully-funded PhD alongside your medical degree.
Get in Touch
Contact Dr Georgina Binnie-Wright, Postgraduate Programme Manager.
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