Resistin: Leukaemia's Secret Weapon Against the Immune System

Closing date: 07/03/2025

MB-PhD Project: Resistin: Leukaemia’s Secret Weapon Against the Immune System

Lead Supervisors: Dr Kiran Batta
Co-Supervisors: 
Dr Mark Williams, Dr Jamie Honeychurch

Applications Deadline: Friday 7th March 2025

Project Keywords: Blood Cancers, Immune Suppression, Novel Therapies
Research Opportunity: Intercalated PhD, leading to the award of PhD and MBChB

Project Outline

Cancer cells employ a variety of mechanisms to evade detection by the body’s immune system, enabling their own growth and survival. Understanding these mechanisms could help restore the functional immune system and eliminate cancer cells. In our group, we have discovered that in myeloid blood cell cancers, the cancer cells produce excessive amount of a protein called Resistin.  Preliminary data suggests that elevated Resistin levels in the plasma of myeloid cancer patients weaken their immune system and are associated with poor overall survival.

As a prospective student, your initial focus will be to investigate clinical parameters, such as the mutational signatures, immune cell landscape, and related comorbidities, that correlate with Resistin levels across myelodysplastic syndromes, myeloproliferative neoplasms and their overlapping diseases. This will help us stratify patients who may benefit from immunotherapy-related approaches and also serve as a biomarker for therapy response or occurrence of comorbidities e.g. cardiovascular events. Additionally, you will explore the molecular mechanisms by which Resistin contributes to immune suppression using state of the art techniques. This knowledge will help us develop novel strategies for targeting immune suppression and test them in patient samples.

As a member of our research team, you’ll collaborate with a multidisciplinary group of consultant haematologists and academic researchers at The Christie Hospital and Manchester Cancer Research Centre. You’ll also join a diverse international community of researchers focused on translational science. This studentship will provide opportunities to develop expertise in advanced cellular and molecular biology techniques e.g. transcriptomics, CyTOF, differentiation assays, cytokine profiling and biomarker identification. Furthermore, there is potential for collaborative work with our partners in the UK and Europe. You’ll receive invaluable mentorship from leading clinician-scientists and haematologists and have the opportunity to present your research at national and international conferences.

About Dr Kiran Batta (project Lead Supervisor)

Kiran Batta is a lecturer in cancer Biology in the Division of Cancer Sciences, The University of Manchester. In 2017, Kiran was awarded Oglesby Leukaemia Research Fellowship to start his independent group. Kiran’s research focuses on understanding epigenetic dysregulation leading to the onset and progression of leukaemia. In close collaboration with clinician scientists at The Christie hospital, Kiran’s lab is working towards identifying potential molecular targets for therapeutic benefit in leukaemia patients.

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